butabarbital will lessen the extent or impact of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Influence of coadministering a strong CYP3A4 inducer with fedratinib has not been studied.butabarbital will reduce the extent or effect of glecaprevir/pibrentasvir by impacting hepatic/intestina… Read More